Vol. 11, Special Issue 5 (2022)

Author(s):
Shravya BLG, Ravindranath BM, Sahadev A, Kalmath GP, Renukaradhya GJ and Suchitra BR

Abstract:
The study was conducted to ascertain the haemato-biochemical, ultrasonographic and histopathological changes associated with cystic endometrial hyperplasia (CEH)-pyometra complex in dogs and also to correlate uterine wall thickness with haemato-biochemical and histopathological changes. Dogs presented to clinic at the Department of Veterinary Gynaecology and Obstetrics were selected for the present study as control (Group I) and pyometra group (Group II) which were subjected to ultrasonographic examination and haemato-biochemical evaluation. Uterine tissue samples collected after ovariohysterectomy were subjected for histopathological evaluation. On trans-abdominal ultrasonography, an increase in the uterine wall thickness (4.28±0.32 mm) and uterine horn diameter (32.85±13.75 mm) was observed in CEH- pyometra cases. Absolute leukocytosis with neutrophilia and lymphopenia were prominent hematological changes whereas, elevation in BUN, creatinine, ALT and total protein level along with hypoalbuminaemia were significant findings in serum biochemical profile of dogs with CEH- pyometra complex. Considerable alterations were found in the histological architecture of uterine tissue in CEH- pyometra affected dogs compared to control group animals. However, there was no significant correlation between uterine wall thickness and haemato-biochemical profile as well as histopathological changes in CEH- pyometra affected dogs in the present study.