Vol. 7, Issue 6 (2018)

Author(s):
Anjali Sharma, Aparna Thakur, Rupinder Virk, Meenu Khurana and Rupinder kaur

Abstract:
Skeletal muscle has a highly complex structure and shaving a numerous roles animal body. A set of inhouse satellite has an interal role in the regeneration pathway forming new myofibers post tissue damage due to injury or a degeneration. On getting a signal of from necrosis in muscle fibres, satellite cells get activated, have an asymmetric division to self-generate, and form activated myoblasts capable of proliferating and reaching the site of damage, and bind to the already present myofibers or create newer ones. It is known that Tristetraprolin, an RNA-binding protein involved in the regulation of cytokine expression has a function of muscle regeneration. Tristetraprolin is present in humans, mice and rats. It is encoded by the Zinc Ring Finger Protein 36 gene. In this study, we have elucidated the role of Tristetraprolin in muscle regeneration by using insilico approaches.