Evaluation of the activity of Garcinia kola seed oil and honey on skin cream formulation
Ordu JI, Sunday BR and Okafo SE
The Garcinia kola seed oil was extracted by solvent extraction and the yield of the oil was 8.50%. The oil was characterized were based on density, pH, saponification, acid value and iodine value. Elemental analysis of the oil was determined and antimicrobial activities of the oil and honey both singly and in combination were assessed using agar diffusion method and the sensitivity pattern of the bacteria (E. coli, Klabsiella pneumonia and Staphylococcus aureus) assessed was varied found to be concentration dependent. Honey at 25% w/w, 50% w/w and 75% w/w concentration inhibited growth of tested organisms except Staph. Aureus, while the G. kola seed oil, was most active against E. coli and Staph. Aureus with zone of inhibition ranging from 14.16 to 2.13mm and 14.33 to 5.12mm respectively but less active against K. pneumonea with zone of inhibition in the range of 12.24 to 2.01mm. Creams were formulated using the extracted G. kola seed oil and honey alone and in combination then evaluated for some physicochemical parameters as: smear, emmolliency, spreadability, homogeneity and pH. Combination of the G. kola seed oil and honey had synergistic effect and formed a better and stable cream than either of the ingredients used alone for the cream formulation.
How to cite this article:
Ordu JI, Sunday BR, Okafo SE. Evaluation of the activity of Garcinia kola seed oil and honey on skin cream formulation. Pharma Innovation 2018;7(5):675-681.