The justification of the use of antihypoxant therapy on the basis of study the dynamics of calcium, parathormone, phosphorus and morphological changes of the parathyroid glands in postoperative hypoparathyroidism in the experiment
Skrypko VD and AYA Pasko
The purpose of our work was to study the manifestations of early postoperative hypoparathyroidism taking into account of morphological and histochemical changes of parathyroid glands (PTG) after thyroidectomy in the experiment and to substantiate the use of antihypoxant-antioxidant therapy in the postoperative period. Taking into account the urgency of this complication in endocrine surgery, the severity of the consequences of hypocalcemia in the early postoperative period, especially an important social aspect of the permanent form of postoperative hypoparathyroidism, the issue of postoperative medical correction is urgently needed for the rapid recovery of functional capacity of the injured patients during operation of the parathyroid glands. Therefore, experimental work to determine morphological changes in the parathyroid glands during thyroidectomy was performed and the process of restoration of ischemic parathyroid glands under the influence of antioxidant antihypoxant therapy was demonstrated. Modeling of hypoparathyroidism was performed according to Lopukhin Yu.M. (1971). The experiment involved 20 animals (rabbits). Animals were divided into 2 groups taking into account the management of post-operative period. Group 1 (9 animals) in the postoperative period for the purpose of analgesia received 50% solution of Analgin intramuscularly at a dose of 2 ml twice a day, for the purpose of detoxification (through the constant catheter) NaCl 0.9% was administered intravenously at a dose of 100 ml per day twice. Group 2 (9 animals), in addition to the above-mentioned treatment, received the medicine Cytoflavin at a dose of 1.5 mg/kg 2 times a day during 7 days intravenously. The control group included 2 rabbits, which were removed PTG, and then their morphology was studied normally. It has been found by us, that surgical interventions on the thyroid gland are accompanied by laboratory and morphological changes in the parathyroid glands, while degenerative-destructive reactions are intensified until the third day of the experiment and their signs stay at the seventh day. The use of antioxidant-antihypoxant therapy, in particular, medicine Cytoflavin, reduces the manifestations of negative laboratory and pathologic morphological changes during the third day and up to the seventh day there are compensatory-reconstructive manifestations in the structural organization of PTG.
How to cite this article:
Skrypko VD, AYA Pasko. The justification of the use of antihypoxant therapy on the basis of study the dynamics of calcium, parathormone, phosphorus and morphological changes of the parathyroid glands in postoperative hypoparathyroidism in the experiment. Pharma Innovation 2018;7(3):354-358.