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Vol. 5, Issue 7 (2016)

Extract-based microemulsion formulation with Solanum aethiopicum peduncle: characterization by DLS, relative humidity and F0 anti-proliferative effect on leukemia cancer cells

Author(s):
Dr. Kouassi Kouadio Christian, Dr. Sorokina Elena Anatolievna, Pr. Mamyrbékova-Békro Janat Akhanovna and Pr. Békro Yves-Alain
Abstract:
The appropriated type of formulation for an efficient bioavailability of phytocompounds (PCD) and plant extracts still a huge challenge for scientists and pharmaceutical industries as extracts generally contain multiple of hydrophobic and hydrophilic substances with different solubility. Even though the richness of Solanum aethiopicum L. (Solanaceae) in bioactive substances has already been reported, never the crude extract (F0) has been used in a formulation in order to assess the best way of administration of the embedded phytochemicals. The aim of this work is firstly to manufacture an extract-based microemulsion (µEm Labrasol-F0), characterize its stability and secondly, to evaluate the anticancer activity of F0 on Jurkat cells. Dynamic light scattering (DLS) results show that the particles size distribution in F1-F4 is ranged from 128 ± 14.6 nm (0.1 µm) to 3862  772 nm (4 µm). Hygroscopic values in 97 % K2SO4 RH attest a better stability of µEm Labrasol-F0, F0- F4 moreover, F0 has anti-proliferative effect against Leukemia cancer cells.
Pages: 80-85  |  1143 Views  23 Downloads
How to cite this article:
Dr. Kouassi Kouadio Christian, Dr. Sorokina Elena Anatolievna, Pr. Mamyrbékova-Békro Janat Akhanovna, Pr. Békro Yves-Alain. Extract-based microemulsion formulation with Solanum aethiopicum peduncle: characterization by DLS, relative humidity and F0 anti-proliferative effect on leukemia cancer cells. Pharma Innovation 2016;5(7):80-85.
The Pharma Innovation Journal