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Vol. 8, Issue 9 (2019)

Study on the therapeutic effect of hepatocytic stem cells in hepatic deficient canine patients

Author(s):
Rashmi Saini, NS Jadon, Priyanka Pandey, Manjul Kandpal, Ramanpreet Singh Sandhu and Arun Kumar
Abstract:
The aim of this study was to determine the therapeutic efficacy of hepatocytic stem cells for hepatic regeneration in dogs. Twenty four canine patients suffering with hepatic dysfunction were divided into four groups i.e., A, B, C and D. The animals were subjected to different treatments viz group A (Control), group B (Inj. pepsid-C @ 1ml/10 kg b.wt. IM alternatively for 15 days), group C (hepatocytic stem cells @ 5 × 107 cells transplanted into peritoneal cavity of affected animal thrice at an interval of 5 days intraperitonially alternatively for 15 days) and group D (hepatocytic stem cells @ 5 × 107 cells transplanted into peritoneal cavity of affected animal thrice at an interval of 5 days + Inj. pepsid-C @ 1ml/10 kg b.wt. IM alternatively for 15 days IM).The efficacy of treatment was assessed by observing various haematological (Hb, TEC, TLC, DLC, PCV, BT and CT), biochemical (serum total protein, serum albumin, serum gluose, serum urea nitrogen, serum creatinine serum AST, serum ALT and serum GGT) changes. Pepsid-C and hepatocytic stem cells combination have better effect on liver regeneration, followed by hepatocytic stem cells (group C) alone and pepsid-C (group B) alone. Hence, hepatocytic stem cells+ pepsid-C combination can be used safely by veterinarians for the treating various hepatic disorders in canine patients.
Pages: 12-17  |  223 Views  6 Downloads
How to cite this article:
Rashmi Saini, NS Jadon, Priyanka Pandey, Manjul Kandpal, Ramanpreet Singh Sandhu and Arun Kumar. . The Pharma Innovation Journal. 2019; 8(9): 12-17.
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