Vellarugu (Enicostemma Littorale Blume) is a swallow-wort plant found in all dry, barren and high grounds. Its botanical name synonyms are Enicostemma axillare (Lam.) and Adenema Hissopifolia. In Tamil it is called vellarugu, arukumuli, chakkiraviraiyantan, in English as Whitehead and its common name is Chota-kirayata. It is an eminent plant used in Tamil siddha medicine, ayurveda, allopathic, homeopathy treatments and home remedies. It is used in the treatment of breathing problems, cough, colds, cholera, eye problems, eczema, flu, hair lice and itching, jaundice, migraine, poisonous bites urinal problems and wounds. Achyranthens aspera or naayuruvi is a powerful ayurvedic herb belong to the family Amaranthaceae and it has been traditionally used in the topical management of wounds. An herbal formulation is prepared with an equal proportion of vellarugu dried plant materials and Achyranthens asperia juice mixed with lime powder for treating wounds in cattle. This herbal preparation is applied topically on the wound and repeated 2-3 times a day. Healing status was monitored macroscopically by observing the wound size and stages, daily, it completely cures the wound in 4-7 days according to the severity. The astringent and anti-inflammatory properties of vellarugu and naayuruvi formulation help clean wounds and promote tissue regeneration. This formulation may be suggested as an efficient and cost-effective home remedy for the treatment of wounds. Further detailed clinical evidence supporting this study’s results would expand the application of this home remedy in wound treatment in livestock.