Systematic analysis of Ocimum sanctum revealed key genes and pathways related to various molecular processes and pathways
Nidhi Sukhija, Chethan Raj R, Rangasai Chandra Goli, Komal Jaglan, Pallavi Rathi, Aishwarya Dash, Kiyevi G Chishi, Mahantesh Shetkar and Kanaka KK
The plant kingdom is a significant source of phytoconstituents with therapeutic potential, many of which may one day lead to the creation of novel chemical entities for a variety of pathological conditions. Alternatives to antibiotics that boost growth performance, gut health, and immunity without having any unfavourable side effects are regarded as phytogenic feed additives. Ocimum species (holy basil) have a high index in a variety of pharmacological activities. The aim of this study was to assess the phytogenic constituents of Ocimum sanctum from literature and find their interacting genes and pathways involving various molecular processes, diseases etc., in this study binding DB database was used to find interacting components and Cytoscape for visualization. A total of 50 high confidence phytochemicals are considered for this study. Binding DB database has found a total of 116 interacting genes and their involvements in different pathways. Notably, EGFR gene for EGFR tyrosine kinase inhibitor resistance, Endocrine resistance. CA1 gene for metabolic pathways and Nitrogen metabolism etc., this approach will be helpful in designing herbal therapy and to support scientifically for the promotion of traditional herbs.
How to cite this article:
Nidhi Sukhija, Chethan Raj R, Rangasai Chandra Goli, Komal Jaglan, Pallavi Rathi, Aishwarya Dash, Kiyevi G Chishi, Mahantesh Shetkar and Kanaka KK. Systematic analysis of Ocimum sanctum revealed key genes and pathways related to various molecular processes and pathways. The Pharma Innovation Journal. 2023; 12(9S): 1504-1509.