Vol. 12, Special Issue 9 (2023)

Author(s):
Vemula Sravathi, Ratna Supriya, RaviKumar Yadala, Swathi Bora, Poloju Deepa, Koppu Vasavi, Donga Durga Veera Hanuman and Kamishetti Mounika

Abstract:
5-Fluorouracil (5-FU) is a widely used chemotherapeutic agent in the treatment of various solid tumors. Several potential pathways have been proposed, including endothelial dysfunction, oxidative stress, mitochondrial damage and disturbances in calcium homeostasis. Additionally, 5-FU may lead to coronary artery spasms, inflammation and direct cardiomyocyte toxicity. These mechanisms often act synergistically, exacerbating the overall cardiotoxic effect. This review article aims to provide a comprehensive overview of the mechanisms underlying 5-FU-induced cardiotoxicity, risk factors associated with its occurrence and the current strategies for prevention and management.