5-Fluorouracil-induced cardiotoxicity: An updated brief review
Author(s):
Vemula Sravathi, Ratna Supriya, RaviKumar Yadala, Swathi Bora, Poloju Deepa, Koppu Vasavi, Donga Durga Veera Hanuman and Kamishetti Mounika
Abstract:
5-Fluorouracil (5-FU) is a widely used chemotherapeutic agent in the treatment of various solid tumors. Several potential pathways have been proposed, including endothelial dysfunction, oxidative stress, mitochondrial damage and disturbances in calcium homeostasis. Additionally, 5-FU may lead to coronary artery spasms, inflammation and direct cardiomyocyte toxicity. These mechanisms often act synergistically, exacerbating the overall cardiotoxic effect. This review article aims to provide a comprehensive overview of the mechanisms underlying 5-FU-induced cardiotoxicity, risk factors associated with its occurrence and the current strategies for prevention and management.
How to cite this article:
Vemula Sravathi, Ratna Supriya, RaviKumar Yadala, Swathi Bora, Poloju Deepa, Koppu Vasavi, Donga Durga Veera Hanuman and Kamishetti Mounika. 5-Fluorouracil-induced cardiotoxicity: An updated brief review. The Pharma Innovation Journal. 2023; 12(9S): 1178-1186.