Vol. 12, Special Issue 8 (2023)

The present investigation was designed with the preceding information in mind. The objective of the project was to optimize the methodology for screening and determining the efficacy of chosen plants as antidiabetic potentiates by observing whether glucose utilization and insulin secretion increased during treatment or not. The parameters used to validate the models will be used in the future to rigorously identify the hypoglycemic effect (s) and mechanism (s) of the plants, once the best possible methodology has been established through this particular research. The study was aimed in establishing a polyherbal formulation ISDM-007 prepared from hydro alcohol extract of Azadirachta Indica leaves, Ocimum Sanctum leaves, Boerhaavia diffusa flowers and Aegle marmelos fruits for its anti-diabetic activity.