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Vol. 12, Special Issue 8 (2023)

Effect of fenbendazole and ivermectin on antioxidant status of goats suffering from gastrointestinal nematodes

Author(s):
AS Rathor, Prakash Bhatt, Stuti Vatsya, JL Singh, Rajesh Kumar and SK Dubey
Abstract:
A total of 146 goats having FAMACHA score from 3 to 5 were examined for estimating the occurrence of gastrointestinal (GI) nematodosis in Tarai region around Pantnagar. Hundred and three goats were found positive for GI nematodosis. Out of these 103 goats, 18 goats were separated and divided randomly in three groups. The animals of Group I: (n=6) were treated with fenbendazole @ 5 mg/kg body wt. po; Group II: (n=6) were given ivermectin @ 0.2 mg/kg body wt. po. The animals of Group III: (n=6) were the control without any treatment. Using standard procedures, the serum obtained were assayed for estimation of antioxidant values and lipid peroxidation viz glutathione peroxidase (GSH-Px), catalase (CAT) and superoxide dismutase (SOD). On 21st day post treatment, goats of group I & II showed significant reduction in lipid peroxidation however values of CAT, SOD & GSH-Px increased significantly. Values of group III showed elevated values of malondialdehyde (MDA) & reduced levels of GSH-Px, SOD and CAT.
Pages: 31-35  |  455 Views  220 Downloads
How to cite this article:
AS Rathor, Prakash Bhatt, Stuti Vatsya, JL Singh, Rajesh Kumar and SK Dubey. Effect of fenbendazole and ivermectin on antioxidant status of goats suffering from gastrointestinal nematodes. The Pharma Innovation Journal. 2023; 12(8S): 31-35.

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