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Vol. 12, Special Issue 7 (2023)

Efficacy of Enrofloxacin in the therapeutic management of bacterial lower urinary tract infection (Cystitis) in geriatric dogs

Author(s):
Jupaka Shashank, K Satish Kumar, VVV Amruth Kumar, B Anil Kumar and M Lakshman
Abstract:
Out of 134 geriatric dogs diagnosed with bacterial lower urinary tract infection (BLUTI) at veterinary clinical complex, college of veterinary science, Rajendranagar, 20 cases with cystitis that were confirmed by history, clinical symptoms, urinalysis, Haemato-biochemical and biomarker estimations, imaging techniques and cultural studies, were selected for therapeutic studies, by randomly dividing them into two groups viz., Group I and II, with 10 dogs in each. Therapeutic regimen for Group I cystitis dogs included Punarnava herbal drug and in Group II an antibiotic, enrofloxacin that have showed highest sensitivity on in vitro antibiogram for the isolates (same/ different) of that particular group dogs with cystitis. The efficacy of treatment regimens was assessed on day 15 by recording remission of clinical symptoms, near normalization of abnormal findings of urinalysis, Haemato-biochemical and biomarkers estimations, disappearance of abnormal ultrasonographical findings and microbiological cure by cultural studies after therapy. Alleviation in frequency and severity of the clinical signs was observed from 7th day of therapy among 4 dogs but with complete improvement among 7 dogs by 15th day. Non-significantly reduced haematological parameters like Hb (11.36±0.58 g/dl), TEC (5.36±0.30 X106/µl) and PCV (37.52 ± 0.44%) of group II dogs showed improvement and reached normalcy by 15th day. Irregular contour of bladder wall surface, sludge, and hyperechoeic debris in the bladder lumen along with thickened urinary bladder wall ranging from 5 mm to 17 mm. Microbiological cure on 15th day of therapy was 70% only in this group of dogs with cystitis.
Pages: 1100-1105  |  206 Views  141 Downloads
How to cite this article:
Jupaka Shashank, K Satish Kumar, VVV Amruth Kumar, B Anil Kumar and M Lakshman. Efficacy of Enrofloxacin in the therapeutic management of bacterial lower urinary tract infection (Cystitis) in geriatric dogs. The Pharma Innovation Journal. 2023; 12(7S): 1100-1105.
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