Vol. 12, Special Issue 12 (2023)
Developing breeding strategies for rodent models as per the different patterns of lethal gene inheritance
P Satheeshkumar, R Selvam, R Priyadharsini and PN Richard Jagatheesan
Understanding the similarities between human and rodent genes with genetic defects and inherited patterns is important in the field of drug discovery and development. Till date, there are more than 1500 human gene with disease or lethal condition and each condition has distinct inheritance pattern and show differences in the expressivity. Several studies revealed that sequence conservation at the nucleotide level between humans and rodents found only a small difference (Lopez -Bigas et al., 2004). These studies mostly revealed the genetic basis of diseases and related mutational changes at nucleotide level which are not sufficient to u se in drug discovery and treatment of the genetic basis of diseases. There will be a lot of attention required to understanding of the unique segregation and inheritance pattern of gene sets of a particular disease. These inheritance pattern s are thoroughly examined and detailed discussion about breeding program s with appropriate pedigree charts will be the main aim of this article.
How to cite this article:
P Satheeshkumar, R Selvam, R Priyadharsini and PN Richard Jagatheesan. Developing breeding strategies for rodent models as per the different patterns of lethal gene inheritance. The Pharma Innovation Journal. 2023; 12(12S): 599-602.