Vol. 12, Special Issue 11 (2023)

Author(s):
Nishchal Thakur, Harmeet Singh Dhillon, Robin Kaura, Mukul Sain, Mohammad Rizwan and Shilpa Vij

Abstract:
Mucormycosis, a formidable and often lethal fungal infection, presents a growing challenge in the realm of infectious diseases. Conventional treatment approaches face limitations, urging exploration into innovative defense strategies. This review delves into the antifungal potentials of cow colostrum whey-derived components—lactoferrin and peptides—as promising candidates in the battle against mucormycosis-causing Molds. The overview introduces the rising incidence of mucormycosis, its clinical complexities, and the imperative for alternative therapies. Subsequently, we explore the antifungal properties of lactoferrin, elucidating its multifaceted role in iron sequestration, direct microbial inhibition, and immunomodulation. A parallel investigation into the diverse antifungal peptides within cow colostrum whey unveils their unique mechanisms, stability, and potential applications. A critical revelation lies in the observed synergistic effects between lactoferrin and peptides, manifesting as complementary mechanisms, enhanced antifungal efficacy, and reduced potential for resistance.