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Vol. 12, Special Issue 11 (2023)

A study on humoral immune response, cellular immune response and delayed type of hypersensitivity reaction, on oral administration of organic selenium in Wistar Albino Rats (Rattus norvegicus)

Author(s):
K Nagaraja, Sanganagowda Koppad, Shesharao, NB Shridhar, U Sunilchandra and BM Chandranaik
Abstract:
An experiment was undertaken to examine the humoral immune response, cellular immune response and delayed type of hypersensitivity reaction, on oral administration of organic selenium in Wistar Albino Rats. The experimental rats were included in four groups of six each. Group I rats receiving distilled water, served as control and Group II got organic selenium, Group III received an antigen, served as antigen control and Group IV given an antigen with organic selenium administered orally. Group III administered antigen on day 14 and 20. The blood samples were collected on day 0, 14, 20, 28, 35 and 42. Leukocyte count (TLC), lymphocyte count (ALC) and Phagocytic indices were increased significantly (p<0.05) in both groups compared with their respective control groups. In Group II, TLC were increased on days 35 and 42 and in Group IV on days 20, 28, 35, and 42, when compared to the groups I and II. In both the group II and IV, increase in ALC and PI values was seen on day 28, 35 and 42, compared with group I and III. In contrast to control groups I and III, no significant (p>0.05) increase in skin thickness in groups II and IV, was observed showing that organic selenium might promote both humoral immune response and cellular immune response without affecting delayed type of hypersensitive reaction.
Pages: 1545-1549  |  70 Views  37 Downloads
How to cite this article:
K Nagaraja, Sanganagowda Koppad, Shesharao, NB Shridhar, U Sunilchandra and BM Chandranaik. A study on humoral immune response, cellular immune response and delayed type of hypersensitivity reaction, on oral administration of organic selenium in Wistar Albino Rats (Rattus norvegicus). The Pharma Innovation Journal. 2023; 12(11S): 1545-1549.
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