Vol. 11, Special Issue 9 (2022)

Author(s):
Vipin K Yadav, Anil K Gangwar, Sangeeta D Khangembam, Ravi P Goyal, Yogendra Singh and Prafull Kumar

Abstract:
The present study was conducted to evaluate the effect of platelet rich plasma (PRP) in healing of critical sized bone defect in New Zealand white rabbits. Caprine aorta was decellularized by an herbal decellularization agent soapnut pericarp (Sapindus mukorossi). Further prepared aortal scaffold was implanted in critical size defect in radius bone. Rabbits were divided in two groups. Group I was implanted with scaffold alone, Group II was implanted with aortal scaffold and platelets rich plasma. The analysis was done by histology, serum calcium, phosphorus and alkaline phosphatase levels, ontogenesis by radiography. Radiographic score shows better healing in PRP treated group. Biochemical studies shows alkaline phosphatase level came to near normal level in group II at 12 weeks. Overall, from analyzing parameters it was found that Group II (treated with aortal scaffold and PRP) was most efficient in bone healing than group I (aortal scaffold alone).This concludes that adopted method requires certain modification for complete bone healing in given time.