Vol. 11, Special Issue 8 (2022)

Methods: Twelve bitches were divided into two groups and were injected with pre-anaethestic (Butorphanol @ 0.2mg/kg, Acepromazine @ 0.05 mg/kg, & Atropine sulphate @ 0.02mg/kg BW) intramuscularly. Propofol alone (@ 4mg/kg BW) or ketofol 1:1 (propofol @ 2mg/kg + ketamine @ 2mg/kg BW) was injected intravenously after 15 min of pre-anaesthetic administration for induction of anaesthesia. The comparison between the drugs was done by employing statistical analysis techniques which were based on cardiorespiratory parameters, induction and recovery time following drug treatment.

Results: Systolic arterial pressure remains comparatively on higher side in ketofol group than the propofol group. Diastolic arterial pressure was maintained significantly on higher level differ at 30 min & 60 min within the ketofol group. The less isoflurane percentage required for maintaince of anaesthesia in the ketofol group than the propofol group. Respiration rate was more stable and non-fluctuating in the ketofol group, which significant differ from propofol group at post induction. Similarly, heart rate was maintained on higher side with significant difference noted following induction of anaesthesia and during surgery in ketofol group. Oxygen saturation and End tidal carbon dioxide remains stable in both groups with non-significant alteration.