Vol. 11, Special Issue 8 (2022)

Author(s):
Vaidehi N Sarvaiya, Kamlesh A Sadariya, Shailesh K Bhavsar, Aswin M Thaker and Mohsin M Pathan

Abstract:
Cefpirome, the fourth generation cephalosporin class of drug has excellent antibacterial activity against Gram-positive and Gram-negative organisms. Cefpirome is rapidly and widely distributed in body fluids and achieves excellent tissue concentrations which exceed the minimum inhibitory concentrations for most pathogens and recommended as the first line drug for febrile neutropenia. Flunixin meglumine, a non-steroidal anti-inflammatory drug used as adjunctive therapy in the treatment of sepsis in large and small ruminants. Treatment of infective condition with an antibacterial agent alone does not alleviate the inflammation, pain, swelling, fever and other complications that accompany an infective condition. Therefore the present study was undertaken to evaluate alteration in haematological and serum biochemical parameters following multiple intramuscular administration of cefpirome (10 mg/kg of body weight repeated at 12 hours interval) with flunixin meglumine (1.1 mg/kg of body weight repeated at 24 hours interval) in sheep for 5 consecutive days. The results indicated that there was no significant alterations in any of the haematological parameters evaluated, while significant (p < 0.05) alterations were observed in the mean values of serum alanine aminotransferase (ALT) and serum aspartate aminotransferase (AST) on 3^rd, 4^th and 5^th day of drug administration; serum alkaline phosphatase (ALP) on 4^th and 5^th day of drug administration and total protein on day 4 of drug administration as compared to control (day 0). All the significant alterations were within their normal range. On the basis of observation of present study on various hematological and blood biochemical parameters, multiple intramuscular administrations of cefpirome along with intramuscular administration of flunixin meglumine did not affect normal body functioning and the combination is safe in sheep.