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Vol. 11, Special Issue 7 (2022)

Chromium load in hexavalent chromium toxicity in wistar rat

Author(s):
Mylaram Jeevana Latha, M Lakshman, A Anand Kumar, A Gopal Reddy and D Pramod Kumar
Abstract:
Hexavalent chromium salts are recognized as occupational health hazard for more than 160 years. Chromium (Cr – VI) is generally considered 1000 times more toxic than (Cr –III). An experiment was conducted with six dietary groups of female wistar rats. Group I, III and IV are control, vitamin C control and emblica officinalis control groups respectively and group V and VI are ameliorative groups. Group II was provided with potassium dichromate 500ppm in drinking water orally for three months along with basal diet. The final result has been interpreted as there is a significant increase in chromium load in toxin group rats. While group V and VI showed mild to moderate improvement when compared to toxin group. Control group values are apparently normal. From the results of this study it has been concluded the presence of chromium in the water at the rate of 500ppm resulted in significant toxicity and this toxic effect was reduced by protective agent vitamin C and ameliorative agent emblica officinalis.
Pages: 654-656  |  192 Views  43 Downloads
How to cite this article:
Mylaram Jeevana Latha, M Lakshman, A Anand Kumar, A Gopal Reddy and D Pramod Kumar. Chromium load in hexavalent chromium toxicity in wistar rat. The Pharma Innovation Journal. 2022; 11(7S): 654-656.

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