Vol. 11, Special Issue 6 (2022)

Author(s):
Venkata Rao KV, Usha Rani M, Gopala Reddy A, Lakshman M, Kalyani P, Anil Kumar B, Rajender B and Vanitha Sree K

Abstract:
This study was conducted to know the therapeutic efficacy of lactoferrin on haematological parameters in the Non-Alcoholic Fatty Liver Disease (NAFLD) model of male C57BL/6 mice induced by administration of high-fat diet (HFD) + CCl4 (0.5 mg/kg, mixed in olive oil) twice a week via intraperitoneal route for 6 weeks. Thirty-six mice were divided into 6 groups of six animals each. Group 1 served as sham; Group 2 kept as disease Control (HFD + CCl4); Group 3 treated with lactoferrin per se (300 mg/Kg mixed in water) via oral route, Group 4 treated with lactoferrin (300 mg/kg) + HFD + CCl4, Group 5 treated with Lactoferrin (100 mg/kg) + HFD + CCl4 and Group 6 treated with simvastatin (10 mg/kg) + HFD + CCl4.. Blood was collected on the 2nd, 4th and 6th week for the estimation of haematological parameters. The study revealed that lactoferrin dose-dependently prevented elevations in haematological parameters in the NAFLD mice model.