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Vol. 11, Special Issue 6 (2022)

Comparative study of efficacy on mifepristone and intravaginal PGF2α in pyometra in bitches

Author(s):
K Urmila, K Chandrashekar Reddy, K Venkataramana and P Nagaraj
Abstract:
Retrospective data was collected and analysed to record the influence of various factors on incidence of canine pyometra at VCC, C.V.Sc, Rajendranagar, Hyderabad from January 2015 to December 2021 while, the present study focused on efficacy of the treatment with Mifepristone and PGF2α by intravaginally with help of a uterine catheter. Six reproductively sound bitches were considered as control group (Group I), 18 pyometra affected bitches were allotted randomly into 3 groups of 6 each and were treated with different protocols. Group II was treated with Mifepristone @ 2.5 mg/kg body weight per oral route for 5 days. Group III was treated with Mifepristone @ 2.5 mg/kg body weight p.o along with Cloprostenol intravaginal route @ 25 µg in small breed and 50 µg in large breeds. Group IV was treated with Mifepristone @ 2.5 mg/kg body weight along with Lutalyse @ 2.5 mg intravaginal route. Treatment was given until disappearance of clinical signs and confirmed by ultrasonography. Blood samples were collected on day 0, 7 and 14 to record the progress of treatment. Anemia, leukocytosis and neutrophilia were prominent in the haematological analysis while elevated ALP, BUN and creatinine were significant (p<0.05) in serum biochemical profile of dogs affected with pyometra. Ultrasonography was found as an accurate aid in the quantitative and qualitative evaluation in canine pyometra. Salivary arborisation changes was noticed on day 0, 7 and 14 where in partial or no crystallization was observed on day 0, however, crystallization was noticed on day 7 and 14. No observed side effect by the use of intravaginal administration of PGF2α. The efficacy in group II, III and IV were 83.33%, 100% and 100% respectively. In conclusion, combination protocols can be considered a better treatment choice as it resulted in complete evacuation of uterine pus with less side effects and cured the pyometra condition in bitch.
Pages: 1411-1414  |  279 Views  152 Downloads
How to cite this article:
K Urmila, K Chandrashekar Reddy, K Venkataramana and P Nagaraj. Comparative study of efficacy on mifepristone and intravaginal PGF2α in pyometra in bitches. The Pharma Innovation Journal. 2022; 11(6S): 1411-1414.

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