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Vol. 11, Special Issue 6 (2022)

In vitro formulation optimization of hydrogel based artificial tears for dry eyes

Author(s):
Dr. Rakesh Kumar Sharma, Darsh Gautam and Ritesh Rana
Abstract:
Objective: The objective of the present study was to formulate, evaluate & optimize artificial tears formulation for the treatment of dry eyes.
Methods: Carboxymethyl cellulose & Hydroxypropyl methyl cellulose hydrogel based artificial tears formulations were evaluated for clarity, pH, viscosity, surface tension, specific gravity, drop size, freezing point & osmolality.
Results & Discussion: Artificial tears formulations were prepared with different concentration of HPMC and CMC and code from B1 to B18. The solutions prepared with Guar gum & Chitosan in purified water was found turbid & subsequently rejected for the formulation of artificial tears. The formulations were evaluated for clarity, pH, Viscosity & surface tension and screened for further study. Four CMC & HPMC hydrogel based formulations B1, B7, B8 & B9 were selected for further study. The specific gravity, freezing point & osmolality determinations were done on formulations B1, B7, B8 & B9. The formulation optimization studies were done using Sigmaplot® software of Systat software Inc UK on B1, B7, B8 & B9 formulations.
Conclusion: The viscosity, surface tension, dropsize, osmolality for HPMC hydrogel based B8 & B9 formulations containing 0.5%w/v & 0.75% w/v HPMC was found optimum.
Pages: 1242-1246  |  288 Views  134 Downloads
How to cite this article:
Dr. Rakesh Kumar Sharma, Darsh Gautam and Ritesh Rana. In vitro formulation optimization of hydrogel based artificial tears for dry eyes. The Pharma Innovation Journal. 2022; 11(6S): 1242-1246.

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