Vol. 11, Special Issue 6 (2022)

Methods: Carboxymethyl cellulose & Hydroxypropyl methyl cellulose hydrogel based artificial tears formulations were evaluated for clarity, pH, viscosity, surface tension, specific gravity, drop size, freezing point & osmolality.

Results & Discussion: Artificial tears formulations were prepared with different concentration of HPMC and CMC and code from B1 to B18. The solutions prepared with Guar gum & Chitosan in purified water was found turbid & subsequently rejected for the formulation of artificial tears. The formulations were evaluated for clarity, pH, Viscosity & surface tension and screened for further study. Four CMC & HPMC hydrogel based formulations B1, B7, B8 & B9 were selected for further study. The specific gravity, freezing point & osmolality determinations were done on formulations B1, B7, B8 & B9. The formulation optimization studies were done using Sigmaplot^® software of Systat software Inc UK on B1, B7, B8 & B9 formulations.

Conclusion: The viscosity, surface tension, dropsize, osmolality for HPMC hydrogel based B8 & B9 formulations containing 0.5%w/v & 0.75% w/v HPMC was found optimum.