Vol. 11, Special Issue 6 (2022)

Author(s):
Hitesh K Bagri, Manoj Sharma, Manisha Sethi, Nadeem Shah, Anusmita Baishya, Pratyush Kumar, Mukesh Bhakat and Tushar K Mohanty

Abstract:
Pyometra (pus in the uterus) is a common disease entity in intact female dogs during the luteal phase. Progesterone appears to be a crucial component in the pathogenesis of pyometra. Pyometra in canines results from hormonal imbalance; sequelae of cystic endometrial hyperplasia. Although the etiopathology of its primary aspect is unknown; however, the intact bitches experience hormonally mediated alterations in the endometrium as a result of recurrent and sustained estrogen responses followed by extensive intervals of progesterone dominance. When the endometrium is damaged by bacterial invasion, alterations in endometrial steroid receptors can cause pyometra.