Vol. 11, Special Issue 6 (2022)

Author(s):
Lahane KS, Ranvir GD, Rajurkar SR, Patil DP, Jadhav ND, Gangane GR, Ghorpade PB and Gaikwad SS

Abstract:
The present study was carried out to evaluate the effect of Morinda citrifolia fruit extract coated SNPs on sub-acute oral toxicity in wistar rats. SNPs synthesized by biological reduction of (AgNO3) with neem 5% extract. SNPs synthesis and coating were confirmed colour pale yellow to dark brown. TEM used for characterization. In this study 50 wistar rats of either sex were divided into 5 groups, each group contain 10 rats. Group I (control), Group II (Low dose), group III (Medium dose), group IV (High dose) and group V (Satellite, highest dose). All treatment groups given orally with 0.17 mg/kg SNPs common offered with given McFE,100 mg/kg McFE (G- II), 200mg/kg McFE (G- III), 400mg/kg McFE (G-IV) and Satellite group (G-V) 800 mg/kg McFE and observed extra 14 day after trial to assess post withdrawal effect of treatment. The haemato-biochemicals observations note within normal limits suggest no adverse effect at all dose.