Dimethoate induced haemato-biochemical alterations and their amelioration by leaves powder of Hibiscus rosa sinensis in Kaveri birds
Bawanthade UR, Moregaonkar SD, Gangane GR, Dr. Kondre BM, Chavan RS, Kachave PB, Swami SB and Pathade DS
The present work was undertaken to investigate the haemato-biochemical changes in dimethoate (an organophosphate) fed Kaveri birds. In addition, their amelioration by leaves powder of Hibiscus rosa sinensis was assessed. Hundred newly hatched day old, unsexed Kaveri birds were procured for the study. All birds were acclimatized for a period of seven days and then evenly split into four groups of 25 birds each. The group-I served as healthy control and was given standard feed and water ad libitum. The birds of groups II were toxicated daily with a solution of dimethoate @ 5.5 mg/kg [1/10th of LD50%] bodyweight through oral gavage. The birds of group III were treated as a plant control group and fed with a Hibiscus rosa sinensisleaves powder @ 1 % of feed daily. The birds in group IV were treated with dimethoate @ 5.5 mg/kg body weight daily through oral gavage + Hibiscus rosa sinensisleaves powder @ 1% of feed daily. The present investigation last for the period of 28 days excluding acclimatization period. The blood and serum samples were drawn from wing vein on 14th day and 28th day from the birds in each group for the estimation of haemato-biochemical indices. Significantly decreased hematological parameters i.e., Hb, PCV, TEC, lymphocytes and heterophil (%) counts whereas TLC and blood clotting time (Sec.) were significantly increased. The biochemical parameters such as indicators of liver health (i.e., Mean of AST, ALT and ALP values) and indicators of the kidney (i.e., Mean SUA, Mean BUN) of birds of this group were significantly increased. However, mean serum TP, albumin, globulin and AchE values were significantly decreased in dimethoate fed Kaveri birds in comparison to other heathy control and plant control group birds. The feeding of Hibiscus rosa Sinensis leaves powder against sub-acute dimethoate toxicity showed partial ameliorative effects on haemato-biochemical parameters.
How to cite this article:
Bawanthade UR, Moregaonkar SD, Gangane GR, Dr. Kondre BM, Chavan RS, Kachave PB, Swami SB and Pathade DS. Dimethoate induced haemato-biochemical alterations and their amelioration by leaves powder of Hibiscus rosa sinensis in Kaveri birds. The Pharma Innovation Journal. 2022; 11(6S): 147-152.