Vol. 11, Special Issue 5 (2022)

Author(s):
Aruru Keerthana, Sunilchandra U, Shridhar NB, Vijay Kumar M, Kavitha Rani B, Sheela P and Srinivasan G

Abstract:
The study was designed to evaluate pharmacokinetics of single oral dose of meloxicam with or without co-administration of andrographolide or bromelain in Wistar rats. The pharmacokinetic parameters of meloxicam in Group I (meloxicam @ 5 mg.kg^-1, p.o.), II (meloxicam + andrographolide @ 60 mg.kg^-1, p.o) and III (meloxicam + bromelain @ 50 mg.kg^-1, p.o) revealed no significant change in observed T_max of 4 h in all groups (n=8 per group). The pharmacokinetic parameters were analyzed with High Performance Liquid Chromatography and calculated by using PK Solver^®, version 2.0. The time vs concentration of meloxicam data was found best fit in to noncompartmental model. The C_max of meloxicam was decreased in Groups II, III compared to Group I. The area under curve of meloxicam was decreased in Groups II and III compared to Group I. The half-life of meloxicam was decreased in Group II, while it had increased in Group III compared with Group I. In conclusion, andrographolide had no influence on the pharmacokinetics of meloxicam, while bromelain was found to interfere to result in increased half-life of meloxicam, following co-administration with single oral dose of meloxicam.