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Vol. 11, Special Issue 5 (2022)

Polymerase chain reaction for antigen receptor rearrangements (PARR) for diagnosis of canine lymphoid neoplasia

Author(s):
V Harini, KG Tirumurugaan, M Chandrasekar, GR Baranidharan, K Vijayarani, SMK Karthickeyan and Stella Esther
Abstract:
Lymphoma is a commonly reported neoplasia in dogs. In hematological neoplasms, clonality plays a major role and the diagnostic approaches for characterization and monitoring of the lymphoproliferative disorders in humans are based on the clonality assessment. In canines, the routinely applied biochemical or histological approaches may not be potential application for early detection. A study was conducted in dogs to assess the diagnostic utility of clonality assay for lymphoid neoplasia using whole blood samples. Samples were collected from 74 suspected cases with lymphadenopathy and PARR was performed with different panel of primers and 77.02% cases were positive for clonal expansion. Among the samples that tested positive for the clonality, 96.49% of the cases were of T phenotype and 3.51% cases were of B phenotype. 14.86% of samples were positive for E. canis infection. The correlation of the clinical diagnosis of lymphoma with the PARR assay result was 83.33% among the tested samples.
Pages: 220-224  |  449 Views  200 Downloads
How to cite this article:
V Harini, KG Tirumurugaan, M Chandrasekar, GR Baranidharan, K Vijayarani, SMK Karthickeyan and Stella Esther. Polymerase chain reaction for antigen receptor rearrangements (PARR) for diagnosis of canine lymphoid neoplasia. The Pharma Innovation Journal. 2022; 11(5S): 220-224.

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