Vol. 11, Special Issue 4 (2022)

Author(s):
Deepali Sakunde, Rajiv Ranjan Kumar, Sanjod Mendiratta, Mukesh Gangwar and Pranav Chauhan

Abstract:
Tests based on nucleic acid are vital in the field of medicine, agriculture, and forensics due to their accuracy and rapidness. Some limiting factors hinder the use of these tests, which include the cost of infrastructure, trained workforce, and the cost of reagents. The paper has recently been unitized as a viable and high potential platform for nucleic acid testing. It has gained increasing interest as a platform in the diagnostic field, especially for low-resource settings. Mainly due to its simplicity, cost-efficiency, biodegradability, and biocompatibility. It is predominantly made up of cellulose fibers, allowing fluids to wick through via capillary force. This characteristic confers advantages in sample storage, mixing, filtering, transport, volume control, timing control and multiplex detection. These paper-based assays could minimize the need for highly trained personnel, showing great potential to improve the existing Nucleic acid testing techniques.