Vol. 11, Special Issue 4 (2022)

Author(s):
Dr. Tanvi Sahni, Dr. Sunita Sharma, Dr. Diksha Verma, Dr. Sachin Kumar, Dr. Poonam Sharma and Dr. Surekha Bhatia

Abstract:
A series of novel Schiff bases were synthesized from syringaldehyde by reacting with 2-aminopyridine, 3-aminopyridine, and 4-amino pyridine and evaluated for their antioxidant potential (DPPH assay, FRAP assay, and Phosphomolybdate assay) using ascorbic acid and BHT as standard. The antibacterial potential of these compounds against one Gram-positive (Bacillus subtilis) and four Gram-negative bacteria (Pseudomonas aeruginosa, Escherichia coli, Klebsiella sp., and Enterobacter sp.) revealed that compound III was more effective than standard ampicillin against P. aeruginosa. In silico studies were performed to predict the toxicity and bioactivity of compounds.