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Vol. 11, Special Issue 4 (2022)

Experimental validation of syringic Schiff bases with pyridine moiety as antibacterial and antioxidant agents along with in silico studies

Author(s):
Dr. Tanvi Sahni, Dr. Sunita Sharma, Dr. Diksha Verma, Dr. Sachin Kumar, Dr. Poonam Sharma and Dr. Surekha Bhatia
Abstract:
A series of novel Schiff bases were synthesized from syringaldehyde by reacting with 2-aminopyridine, 3-aminopyridine, and 4-amino pyridine and evaluated for their antioxidant potential (DPPH assay, FRAP assay, and Phosphomolybdate assay) using ascorbic acid and BHT as standard. The antibacterial potential of these compounds against one Gram-positive (Bacillus subtilis) and four Gram-negative bacteria (Pseudomonas aeruginosa, Escherichia coli, Klebsiella sp., and Enterobacter sp.) revealed that compound III was more effective than standard ampicillin against P. aeruginosa. In silico studies were performed to predict the toxicity and bioactivity of compounds.
Pages: 417-426  |  451 Views  198 Downloads
How to cite this article:
Dr. Tanvi Sahni, Dr. Sunita Sharma, Dr. Diksha Verma, Dr. Sachin Kumar, Dr. Poonam Sharma and Dr. Surekha Bhatia. Experimental validation of syringic Schiff bases with pyridine moiety as antibacterial and antioxidant agents along with in silico studies. The Pharma Innovation Journal. 2022; 11(4S): 417-426.

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