Vol. 11, Special Issue 2 (2022)

Author(s):
Dr. Tanya Singh, Dr. Reshma Jain, Dr. BP Shukla, Dr. Nidhi Shrivastava, AS Parihar and Dr. Sonia Parte

Abstract:
Postoperative pain is considered a form of acute pain due to surgical trauma with an inflammatory reaction and initiation of an afferent neuronal barrage. Transdermal drug delivery offers controlled release of the drug into the patient, it enables a steady blood level profile, resulting in reduced systemic side effects and sometimes, improved efficacy over other dosage forms. The present study was planned to evaluate the efficacy of transdermal buprenorphine drug to alleviate the post operative pain after abdominal surgery.12 clinical cases of dogs presented to the Department of Veterinary Surgery and Radiology, VCC, College of Veterinary Science and A.H., Mhow were selected for the study. In group I (n=6) meloxicam was administered and in group II (n=6) buprenorphine transdermal patch was applied to the skin. The Glasgow Composite Measure Pain Scale was used to record the pain at different time intervals. The mean total pain score was more in meloxicam group than the buprenorphine group. Biochemical parameters viz. blood glucose and serum cortisol showed maximum significant increase in meloxicam and minimum in buprenorphine group at complete post recovery. Blood urea nitrogen and serum creatinine showed a non-significant deviation in both the groups and were within the normal levels at different time intervals. On the basis of above study, it was concluded that buprenorphine transdermal patch was considered to be most effective for controlling the visceral pain in comparison to meloxicam in dogs.