Vol. 11, Special Issue 2 (2022)

Author(s):
Shesharao, Suguna Rao, Nagaraja K and Manjunatha KP

Abstract:
The present study was taken up to evaluate the efficacy of Trigonella foenum graecumindividualy and in combination along with glibenclamide in streptozotocin induced diabetic rats for a period of 90 days. The various groups in this study included normal control (Group-I), diabetic control (Group-II), diabetic rats treated with glibenclamide (Group-III), diabetic rats treated with Trigonella foenum graecum (Group-IV), Trigonella foenum graecum and glibenclamide (Group-V), respectively. There was significant variation in histopathological and immunohistopathological parameters of diabetic rats when compared to normal control rats. The alleviation of the diabetic and its complications induced by streptozotocin was obseved in all the treatment groups with variable degree of improvement. Trigonella foenum graecum extracts was effective in alleviating streptozotocin induced diabetes and were comparable with glibenclamide. Combination of Trigonella foenum graecum with glibenclamide showed better improvement compared to individual extracts alone and improvement was statistically significant. However the combined treatment of Trigonella foenum graecum and glibenclamide half dose revealed a very good antidiabetic effect with reference to improvement in insulin level and beta cell number which indicated a synergistic effect between Trigonella foenum graecum and glibenclamide half dose.