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Vol. 11, Special Issue 1 (2022)

Clinico-physiological effect of ketamine, propofol and Ketofol as constant rate infusion anaesthesia during elective ovariectomy in dogs

Author(s):
Agyey Pusp, Archana Kumari, Ramesh Tiwary, Rajesh Kumar, Md Moin Ansari and Abhishek Deep
Abstract:
The present study was carried out on 18 clinical cases of female dogs irrespective of age and weight presented for ovariectomy operation to evaluate clinic-physiological effect of ketamine, propofol and ketofol as CRI anesthesia. The animals were randomly divided into three experimental groups (n=6), were designated as Group I, II and III on the basis of the induction and maintenance agent for elective ovariectomy. All animals were pre-medicated with glycopyrrolate @ 0.01mg/kg b.wt intramuscularly followed by inj. butorphanol 0.2 mg/kg b.wt and xylazine 1mg/kg b.wt intramuscularly after 5 minutes by using different syringes. After 10 minutes of xylazine, animals were induced (till effect) with propofol and immediately just after induction animals were maintained with constant rate infusion of ketamine, propofol and ketofol 1:1 along with normal saline @ 10 ml/kg/hr. During the present study various physiological and clinical evaluations were carried out to evaluate the CRI ketamine, propofol and ketofol in anaesthetic regimen. On clinical parameters, the mean values of recovery time in groups I, II and III were 47.17±0.94 min, 25.00±1.33 min and 46.83±0.60 min respectively. The mean values of sternal recumbency time in groups I, II and III were 61.17±1.81min, 36.17±1.33min and 58.67±1.05min respectively. The mean values of duration of surgery in groups I, II and III were 58.67±1.56 min, 59.00±0.84 min and 57.00±1.60 min respectively. The mean values of duration of anaesthesia in groups I, II and III were 75.5±2.04min, 73.83±2.53 min and 77.17±1.64 min respectively. Physiological parameters showed that the values of rectal temperature in all three groups showed a decrease at different intervals during the observation period in comparison of the baseline values. The values of respiratory rate in all three groups decreased at different intervals during an observation period in comparison to the baseline values. All three groups showed that respiratory rate value decreased significantly (p<.05) after pre-medication and remained significantly lower throughout the observation period. Value of heart rate significantly (P<0.05) increased after pre-medication in all three groups in comparisons to respective base values after that decreased but remained non-significantly (P>0.05) higher in group I and III, however it become non-significantly lower in group II during maintenance of anaesthesia in comparison to respective base values.
Pages: 1291-1296  |  548 Views  315 Downloads
How to cite this article:
Agyey Pusp, Archana Kumari, Ramesh Tiwary, Rajesh Kumar, Md Moin Ansari and Abhishek Deep. Clinico-physiological effect of ketamine, propofol and Ketofol as constant rate infusion anaesthesia during elective ovariectomy in dogs. The Pharma Innovation Journal. 2022; 11(1S): 1291-1296.

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