Vol. 11, Special Issue 1 (2022)

Author(s):
V Sravathi, M Jeevanalatha, Y Ravikumar, A Gopalareddy, T Chandravathi, B Swathi and M Lakshman

Abstract:
The present study was aimed to evaluate protective effect of NARENGENIN (NG) on 5-Flurouracil (5-FU) induced hematological alterations in Wistar rats. A total of forty eight (48) adult male abino Wistar rats were divided into 4 groups each. The group 1 (control), group 2 treated with 5-FU (@ 20 mg/kg b. wt., IP) for 5 days, group 3 administered with NG (@ 100 mg/kg b.wt, P/O) for 28 days and group 4 rats provided with 5-FU (@ 20 mg/kg b. wt) +NG (@ 100 mg/kg b. wt). The experiment was carried out for a duration of 28 days and each group were sacrificed on 14^th and 28^th day of the experiment. Hematological parameters were significantly reduced in group 2 expect TLC and significant improvement of all parameters was noticed in ameliorative group (group 3).