Toll Free Helpline (India): 1800 1234 070

Rest of World: +91-9810852116

Free Publication Certificate

Vol. 11, Special Issue 1 (2022)

5-Flurouracil induced hematological alterations in wistar rats and its amelioration with naringenin

Author(s):
V Sravathi, M Jeevanalatha, Y Ravikumar, A Gopalareddy, T Chandravathi, B Swathi and M Lakshman
Abstract:
The present study was aimed to evaluate protective effect of NARENGENIN (NG) on 5-Flurouracil (5-FU) induced hematological alterations in Wistar rats. A total of forty eight (48) adult male abino Wistar rats were divided into 4 groups each. The group 1 (control), group 2 treated with 5-FU (@ 20 mg/kg b. wt., IP) for 5 days, group 3 administered with NG (@ 100 mg/kg b.wt, P/O) for 28 days and group 4 rats provided with 5-FU (@ 20 mg/kg b. wt) +NG (@ 100 mg/kg b. wt). The experiment was carried out for a duration of 28 days and each group were sacrificed on 14th and 28th day of the experiment. Hematological parameters were significantly reduced in group 2 expect TLC and significant improvement of all parameters was noticed in ameliorative group (group 3).
Pages: 1250-1254  |  320 Views  80 Downloads
How to cite this article:
V Sravathi, M Jeevanalatha, Y Ravikumar, A Gopalareddy, T Chandravathi, B Swathi and M Lakshman. 5-Flurouracil induced hematological alterations in wistar rats and its amelioration with naringenin. The Pharma Innovation Journal. 2022; 11(1S): 1250-1254.

Call for book chapter