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Vol. 11, Special Issue 1 (2022)

PK-PD of marbofloxacin along with meloxicam after single intramuscular administration in buffalo calves

Author(s):
Dinesh MB, SK Sharma, JS Lamba, MM Lonare and Dr. SK Singh
Abstract:
Marbofloxacin is a third generation broad spectrum fluoroquinolone developed exclusively for use in veterinary medicine against many pathogens of veterinary importance. NSAIDs are the most commonly used group of drugs prescribed by physician along with antibiotics. The present study was carried out to investigate the effect of meloxicam administration on the disposition of marbofloxacin at single dose i.e 8 mg.kg-1 in 6 months - 1 year old buffalo calves. Meloxicam (0.5 mg.kg-1) was administered intramuscularly followed by marbofloxacin at 8 mg.kg-1 i.m to the buffalo calves. The concentration of marbofloxacin in plasma was estimated using HPLC. The plasma concentration was maintained upto 12 h. Vdarea of marbofloxacin was found to be 8.7 ± 1.50 L.kg-1 indicating good tissue distribution. The values of Cmax, tmax AUC0-∞ and AUMC found to be 1.19 ± 0.07 µ.g.ml-1, 1.00 h, 6.11 ± 0.60 µg.ml-1.h and 29.26 ± 2.73 µg.ml-1.h2 respectively. The t1/2β, ClB and MRT found to be 4.37 ± 0.28 h, 1.34 ± 0.12 L.kg-1.h-1 and 4.64 ± 0.2 h respectively. The selected dose of marbofloxacin (8 mg.kg-1) administered i.m, along with meloxicam (0.5 mg.kg-1) in buffalo calves was found effective against MIC value ≤ 0.073 µg.ml-1. Meloxicam seems to affect the pharmacokinetic behavior of marbofloxacin remarkably.
Pages: 857-861  |  341 Views  100 Downloads
How to cite this article:
Dinesh MB, SK Sharma, JS Lamba, MM Lonare and Dr. SK Singh. PK-PD of marbofloxacin along with meloxicam after single intramuscular administration in buffalo calves. The Pharma Innovation Journal. 2022; 11(1S): 857-861.

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