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Vol. 11, Special Issue 1 (2022)

Ameliorative effect of Mucuna pruriens on cypermethrin induced toxicity on body weights and organ weights in Wistar rats

Author(s):
Shaik Mohasina, M Jeevanalatha, Y Ravi Kumar, P Shivakumar and M Lakshman
Abstract:
The ameliorative potential of Mucuna pruriens was studied against Cypermethrin induced toxicity. Total 48 adult male Wistar albino rats were divided into 4 groups (n=12). Group I (control) and group II, III, IV rats treated with cypermethrin, Mucuna pruriens, cypermethrin and Mucuna pruriens at the rate of 25, 300, 25 and 300 mg/kg b.wt. respectively orally for 28 days. Six (06) rats from each group were sacrificed on 14th and 28th day of the experiment.
In the present study, weekly body weights were significantly (P<0.05) reduced in group II rats. The absolute and relative weights of testes in group II rats were significantly (P<0.05) decreased on 28th day of study than group I rats. On 14th and 28th day of experiment, a significant (P<0.05) increase in absolute and relative liver weights and a significant (P<0.05) decrease in absolute and no significant change in relative kidney weights were observed in group II rats than group I rats. However, administration of Mucuna pruriens caused a mild ameliorative effect on the parameters investigated.
Pages: 334-337  |  357 Views  91 Downloads
How to cite this article:
Shaik Mohasina, M Jeevanalatha, Y Ravi Kumar, P Shivakumar and M Lakshman. Ameliorative effect of Mucuna pruriens on cypermethrin induced toxicity on body weights and organ weights in Wistar rats. The Pharma Innovation Journal. 2022; 11(1S): 334-337.

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