Vol. 11, Special Issue 12 (2022)

Author(s):
HB Patel, RD Singh, SK Mody, SH Raval and HA Patel

Abstract:
A renal safety evaluation of combination of antimicrobial drugs viz. marbofloxacin and ornidazole was studied to assess clinical impact of their intravenous administration on various renal parameters in sheep. Six healthy male sheep were treated with combination of marbofloxacin (2.0 mg/kg body weight) and ornidazole (20 mg/kg body weight). The urine samples before and after intravenous drug administration of combination at different time intervals (6 h, 12 h, 1, 2, 3, 4, 5, 6 and 7^th day after treatment) were collected and subjected to physical and chemical analysis and microscopic examination. Physical parameters including colour, odour, transparency and pH were studied. The chemical analysis included the assessment of glucose, ketones, proteins, bilirubin etc. The values of all the parameters before and after drug administration were estimated and compared for any alteration using statistical techniques of t-test of significance. The statistical comparison of physical and chemical parameters before and after treatment did not reveal any significant alteration and no animals showed any signs and symptoms of urinary discomfort. No microscopic abnormality was detected in urine sediments. The study indicates the intravenous administration of marbofloxacin and ornidazole combination is well tolerated by sheep, in terms of renal safety, at prescribed dosage.