Vol. 11, Special Issue 11 (2022)

Marbofloxacin, a ‘veterinary-use only’ antimicrobial drug is having potential to treat bacterial infections in poultry species. The present study was aimed at to explore disposition kinetic behaviour of marbofloxacin following its single dose intravenous administration (5 mg/kg body weight) in broiler chickens. The concentrations of marbofloxacin in plasma samples were analyzed by Ultra High Performance Liquid Chromatography (UHPLC) and the data collected were subjected to non-compartmental kinetic analysis. Following single intravenous administration, marbofloxacin presented a relatively high volume of distribution (V_d(ss) = 1.85 L/kg), suggesting its good tissue penetration, and a good total body clearance (CLB) value of 0.31 L/h/kg, along with long elimination half-life (t1/2β = 5.54 h). The average value for area under curve (AUC), area under the first moment of the plasma drug concentration (AUMC) and mean residence time (MRT) were 17.03 µg•h/ml, 106.95 µg.h²/ml and 6.09 h, respectively. The disposition parameters were favourable for the use of drug in poultry species.