Vol. 11, Special Issue 11 (2022)

Author(s):
Uzma Farooq S, Sharma A, Khajuria V, Nabi B and Mahajan D

Abstract:
The experiment was carried out to evaluate the rising concern over additive effect of one chemical with another chemical which have raised a lot of health concern in general population. In the experiment, adult wistar rats of either sex were divided into 4 groups and study was conducted for a period of 28 days. Group I served as control and was provided with water only for drinking purposes. Animals of group II were administered butachlor @ 262 mg / kg B.W / P.O. Group III received administered lead acetate @265 ppm orally while animals of group IV received combination of butachlor @ 262 mg / kg and lead acetate @ 265 ppm. Group IV animals showed significant (p < 0.05) decrease in levels of Hemoglobin, Packed cell volume, Total erythrocyte count, Lymphocytes, Monocytes levels while significant (p < 0.05) increase was observed in Neutrophil, Eosinophils, Basophil, Erythrocyte sedimentation rate. Elevated levels of blood biochemical indices like phosphatases (ACP & ALP), aminotransferases (AST & ALT), Creatinine, BUN was also observed in group IV.