Vol. 11, Special Issue 11 (2022)

Author(s):
Uzma Farooq S, Sharma A, Khajuria V, Nabi B and Mahajan D

Abstract:
The experiment was carried out to evaluate the rising concern over additive effect of one chemical with another chemical which have raised a lot of health concern in general population. In the experiment, adult wistar rats of either sex were divided into 4 groups and study was conducted for a period of 28 days. Group I served as control and was provided with water only for drinking purposes. Animals of group II were administered butachlor @ 262 mg / kg B.W/P.O. Group III received administered lead acetate @ 265 ppm orally while animals of group IV received combination of butachlor @ 262 mg / kg and lead acetate @ 265 ppm. Oxidative stress was revealed by significant increase in lipid peroxidation and decrease in blood glutathione, glutathione peroxidase and transferase, catalase and superoxide dismutase in blood and tissues respectively. Histopathologic ally, liver and kidney exhibited structural alterations as compared to control. The study concluded butachlor and lead produced more deleterious systemic effect in combination than alone (additive toxic effect).