Vol. 11, Special Issue 11 (2022)

Author(s):
Uzma Farooq S, Sharma A, Khajuria V, Singh A and Kour H

Abstract:
Adult Wistar rats of either sex were purchased from the Indian Institute of Integrative Medicine, Jammu and maintained under standard experimental conditions with ad libitum feed and water. The animals were randomly divided into two groups with six rats in each group. The experiment was conducted for a period of 28 days and was given through oral gavage. Group I served as control and was provided with water only for drinking purposes. Group II animals were administered Butachlor (Mancheter EC) @ 262 mg / kg B.W/P.O. Administration of Butachlor @ 262 mg / kg alone produced haemato-biochemical changes. It produced significant (p < 0.05) decrease in levels of Hemoglobin, Packed cell volume (PCV), Total erythrocyte count (TEC), Lymphocytes, Monocytes, Basophils levels while significant (p < 0.05) increase was observed in Total leucocytic count (TLC), Erythrocyte sedimentation rate (ESR), Neutrophil, Eosinophils. Elevation in blood biochemical indices was observed like phosphatases (ACP & ALP), aminotransferases (AST & ALT), creatinine, BUN, Total cholesterol, Triglyceride, LDL but decreased the protein profile and HDL levels.