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Vol. 10, Special Issue 8 (2021)

Evaluation of the extracts of Anthocephalus cadamba, Brassica juncea and Pithecellobium dulce against general toxicity induced by sub-acute exposure of Fipronil in rats

Author(s):
Devendra Singh, Shweta Anand, Rahul Swarnkar, Abhishek Choudhary and Sunil Boghia
Abstract:
The present investigation was carried out to evaluate ameliorating potential of extracts of Anthocephalus cadamba (Kadamba), Brassica juncea (Mustard) and Pithecellobium dulce (Jungle jalebi) against general toxicity induced by sub-acute exposure of Fipronil in rats. Fipronil is a new generation insecticide of phenylpyrazole group used for pest management in agriculture practices. The ameliorative effect of Anthocephalus cadamba (300 mg/kg B.w.), Brassica juncea (300 mg/kg B.w.) and Pithecellobium dulce (300 mg/kg B.w.) were seen against Fipronil (10 mg/kg B.w.). The main clinical signs observed due to toxicity of Fipronil were anorexia, dizziness, abnormal gait, lethargy, weakness and aggressive behaviour. Sub-acute intoxication caused decrease in body weight both absolute and relative body weight which was significantly ameliorated by extracts of Kadamba, Mustard and Jungle jalebi. A significant increase in absolute and relative weight of liver, kidney and lung except spleen due to fipronil was significantly restored by Kadamba, Mustard and Jungle jalebi extracts. It can be concluded that Kadamba (@300 mg/kg B.w.), Mustard (@300 mg/kg B.w.) and Jungle jalebi (@300 mg/kg B.w.) extracts has potential to ameliorate toxicity caused by Fipronil (@10 mg/kg B.w.) induced sub-acute toxicity in rats and fruits extract of Jungle jalebi (@300 mg/kg B.w.) has greater ameliorating potential in comparison to Kadamba and Mustard.
Pages: 818-824  |  403 Views  188 Downloads
How to cite this article:
Devendra Singh, Shweta Anand, Rahul Swarnkar, Abhishek Choudhary and Sunil Boghia. Evaluation of the extracts of Anthocephalus cadamba, Brassica juncea and Pithecellobium dulce against general toxicity induced by sub-acute exposure of Fipronil in rats. The Pharma Innovation Journal. 2021; 10(8S): 818-824.

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