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Vol. 10, Special Issue 8 (2021)

Study on haematobiochemical changes in induced segmental defect in rabbits

Author(s):
Vishwakarma Raj Kumari, Roukuobinuo Houzha, Mridula Sharma, Manjul Kandpal, SK Shukla, NS Jadon and Arup Kumar Das
Abstract:
The present study was conducted in 24 healthy rabbits of either sex approximately 2.0 years of age, weighing 1.8 to 2.0 kg body weight. Prior to experiment each rabbit was examined to assess their health status by clinical, haematological and faecal examination. The surgical procedure was accomplished under premedication with inj. glycopyrrolate @ 0.01 mg/kg, SC (subcutaneously), later inj. xylazine @ 4 mg/kg IM (intramuscularly), and then induction of anaesthesia with inj. Ketamine @ 40 mg/kg IM. A five minutes interval was kept between each of these injections. All haematobiochemical parameters were falls in normal physiological reference range except few viz.; the value of haemoglobin showed a significant (P<0.05) decrease at day 15 of post-operative day and a significant (P<0.05) decrease in values of packed cell volume and total erythrocyte count were observed at day 7 and day 15 post-operative days as compared to its pre-experimental value. Among biochemical parameters serum alkaline phosphatase found significantly increased (P<0.05) from day 7 to day 60, a significant (P<0.05) increase in value of serum calcium was observed at day 7, 15, 30 and day 60, and a significant (P<0.05) increased was observed in value of serum phosphorus from day 7 to day 30 of the post-operative period as compared to its pre-experimental. The value of protein was reduced significantly (P<0.05) that observed at day-7, 15, 30 and day 60 and the blood glucose value showed a significant (P<0.05) increase at day 7 post-surgery as compared to its pre-experimental value. Overall both haematological and biochemical parameters were found within normal physiological reference range except few and these were also returning to pre-experimental values early in the post-operative period.
Pages: 591-594  |  287 Views  55 Downloads
How to cite this article:
Vishwakarma Raj Kumari, Roukuobinuo Houzha, Mridula Sharma, Manjul Kandpal, SK Shukla, NS Jadon and Arup Kumar Das. Study on haematobiochemical changes in induced segmental defect in rabbits. The Pharma Innovation Journal. 2021; 10(8S): 591-594.

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