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Vol. 10, Special Issue 8 (2021)

Pathological studies on subacute toxicity of Amaranthus retroflexus and its amelioration of Ficus religiosa in wistar rats

Author(s):
AR Chaure, GR Gangane, SD Moregaonkar, HJ Shete and AN Choudhari
Abstract:
Background: In India, mixed farming, combining crops and livestock activities have been a way of life since the dawn of civilization. Animals are mostly reared on the basis of low feed cost ratio, hence, for feeding to livestock, grazing is preferred. In some parts of Maharashtra state, there has been drought condition due to this situation; scarcity of fodder for animal is common problem. During grazing, in such situation, animal voraciously eat harmful plants, producing adverse effects on their health and ultimately on production.
Methods: The subacute toxicopathological study was conducted to note toxic effect of Amaranthus retroflexus and its amelioration by Ficus religiosa treatment in Wistar rats. The study was conducted for 28 days and evaluated through histopathological changes 28th day of trial.
Result: At the end of trial, histopathological investigation in organs such as Liver, Kidneys, Intestine, Spleen, Brain, Testes, Lungs, Adrenals and Heart of all experimental rats were attempted. On gross examination, none organ could show remarkable gross pathological change in toxicated as well as other treatment and control group except, minimal hepatomegaly and necrotic foci in female and male rats of group II. However, The experimental male and female rats of group II toxicated by administration of aqueous extract of Amaranthus retroflexus plant for 28 days showed histoarchitechtural changes in liver, kidney, intestine, testes, adrenal and brain. In the rats of group IV which were toxicated with Amaranthus retroflexus and simultaneously treated with Ficus religiosa stem bark powder did not show any appreciable changes in liver, kidneys, heart, intestine, spleen, lungs, brain, testes and adrenals.
Pages: 177-179  |  375 Views  106 Downloads
How to cite this article:
AR Chaure, GR Gangane, SD Moregaonkar, HJ Shete and AN Choudhari. Pathological studies on subacute toxicity of Amaranthus retroflexus and its amelioration of Ficus religiosa in wistar rats. The Pharma Innovation Journal. 2021; 10(8S): 177-179.
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