Vol. 10, Special Issue 7 (2021)

Author(s):
RKR Sangamitra, G Suganya, V Leela and M Balagangadhara Thilagar

Abstract:
The study was conducted to evaluate the Activated thromboplastin time in dogs affected with various hepatic disorders. The study group consisted of control and experimental dogs. The experimental dogs further classified into biliary, neoplastic and parenchymal source of hepatic dysfunction based on ultrasonography. The study was conducted for a period of one year and the citrated plasma sample collected was evaluated for activated thromboplastin time. APTT values in dogs with parenchymal, neoplastic and biliary disorders showed significant increase (P<0.01) when compared to the control group of dogs. Alteration of APTT values in the experimental group indicates significant alteration in the coagulation mechanism in dogs affected with hepatic dysfunction of different etiology. Thus, the results of this study suggest that dogs affected with parenchymal, biliary and neoplastic type of hepatic disorders showed significant prolongation in APTT indicating defect in the coagulation cascade of both intrinsic and common pathway resulted in impaired clotting.