Vol. 10, Special Issue 6 (2021)

Author(s):
Rajat Sagare, MA Kshama, M Narayana Bhat, Suguna Rao, Sharada R and Prakash N

Abstract:
The study was conducted at the Department of Veterinary Medicine, Veterinary College Bangalore with objective to determine the efficacy of cystatin C as biomarker in early diagnosis of renal failure and to predict the progression of renal failure in dogs. Dogs aged above five years with history, clinical signs and laboratory findings suggestive of renal disease were taken up for the study. Based on the creatinine values, animals were randomly divided into 3 groups, Group-I (at risk group), Group-II (renal failure group) and Group-III (control). Serum cystatin C was measured by canine cystatin C ELISA kit. There was a significant difference (P≤0.05) in mean values between Group-II and Group-I as well as Group-II and Group-III while there was no significant difference (P>0.05) in mean values between Group-I and Group-III (control). However, of the 10 animals of Group-I, 6 animals on day 0 and 8 animals on day 28 showed elevation in serum cystatin C levels compared to Group-III (control dogs). Therefore it was concluded that elevated serum cystatin C levels in individual animals in Group-I were indicative of early onset renal failure and serum cystatin C in all animals of Group-II correlated well with increasing creatinine values suggesting that serum cystatin C was a good index to predict the progression of renal failure.