Vol. 10, Special Issue 5 (2021)

Author(s):
B Sampath Kumar, Ramesh HS, Nandi S and Girish Kumar V

Abstract:
The aim of this study is to find out the efficacy of the Aegle marmelos (AM) and Mimosa pudica (MP) plant extracts on the rat ovarian follicular growth. For this both the plant extracts (AM & MP) were administered orally to the white rats (Rattus norvegicus) after being extracted in the soxhlet apparatus with 80 % methanol as a solvent. Before this a total of seven groups of rats (each group consisted of six rats) were maintained, including a control group. Further, both the plant extracts were administered for three successive estrous cycles at the dose of 100, 300, and 1000 mg/kg b.wt. and euthanized. Parameters like body weight (before start & before slaughter), ovarian weight, other organ weights, ovarian follicular number and diameter were measured. The AM @1000, mg/kg b.wt. groups had significantly higher mean surface ovarian follicular number, higher mean preantral follicle number (Small & Large preantral follicel) & higher mean antral follciles (Small & Large antral follicle) than the control group. However, MP @ 1000 mg/kg wt group showed a significantly lower mean number of surface follicles, preantral follicles as well as antral follicles. Likewise, the mean atretic ovarian follicle number was significantly lower in the AM @ 1000 mg/kg b.wt. Group where as higher in the MP @ 300 & 1000mg/kg b.wt. Groups compared to the control. The mean initial and final body weights of all the groups were found to be non-significant. Similarly, no significant differences in mean liver, pancreas, and kidney weights were seen when compared to control. However, higher mean ovarian weight was recorded in the AM @ 1000 mg/kg b.wt. and lower mean ovarian as well as uterine weight was recorded in the MP @ 100,300 & 1000 mg/kg. wt groups compared to the control.