Vol. 10, Special Issue 5 (2021)

Author(s):
S Subapriya, N Pazhanivel, Mohammed Shafiuzama, D Sumathi, C Jayanthy and S Vairamuthu

Abstract:
The present study was undertaken to evaluate the expression of potential tumour biomarkers as diagnostic and prognostic indicators in different cutaneous neoplasms. Immunocytochemical studies on C Kit gene in mast cell tumours showed strong positive expression of C Kit. Immunohistochemical investigation showed expression of cytokeratin in all the epithelial tumours and vimentin in all mesenchymal tumours studied. Among the epithelial tumours, squamous cell carcinoma showed positive expression for the marker Epithelial Membrane Antigen (EMA) in contrary to basal cell carcinoma which showed no expression to EMA. The mesenchymal tumour haemangiosarcoma showed positive expression for CD31. Among the round cell tumours, mast cell tumour showed positive expression to C Kit, B cell lymphoma showed positive expression to CD79a and T cell lymphoma showed positive expression to CD3. Melanoma tumours showed positive expression to both Melan A and S100.