Ameliorating effect of quercetin against fipronil induced subacute toxicity in rats
Durgesh Yadav, Gayatri Dewangan and Neetu Rajput
Fipronil is a class of phenyl pyrazole pesticides used for the control of a wide range of agricultural, public health and veterinary pests. Quercetin, the flavonoid present in several vegetables and fruits possesses a number of pharmacological activities. Present study was conducted to evaluate the ameliorative effect of quercetin against fipronil induced toxicity in rats. Rats were divided in to three groups, having six animals in each group. Group I was treated as control and group II and III received, fipronil (10 mg/kg b.wt) and fipronil + quercetin (10mg/kg b.wt +100mg/kg b.wt) respectively orally daily for 28 days. Blood samples for estimation of biochemical parameters were collected on 0, 14 and 28th days of exposure. The results revealed that fipronil caused significant reduction in body weight of rats during 28 days of exposure which may be due to oxidative stress by induced by fipronil. Fipronil also significantly increased the serum level of AST, ALT, ALP LDH, BUN and creatinine during 28 days of exposure indicated liver and kidney damage by fipronil. However supplementation of quercetin mitigated the adverse effects of fipronil by reducing the elevated level of serum biochemical parameters.
How to cite this article:
Durgesh Yadav, Gayatri Dewangan and Neetu Rajput. Ameliorating effect of quercetin against fipronil induced subacute toxicity in rats. The Pharma Innovation Journal. 2021; 10(2S): 79-82.