The present study aimed to evaluate the anti-colitis actions of SeNP and Dexamethasone in acetic acid induced colitis model in rats. Group 1 was kept as normal control throughout the experimental period. Remaining 3 groups were induced colitis by intra- colonic injection of acetic acid @ 4% (2 ml). Treatment protocols were initiated from day 2 and were continued for next 14 days.
Group 1: Non Colitis control,
Group 2: Acetic acid induced colitis control (UC) (4% concentration @ 2ml, single dose intra colonic),
Group 3: UC + SeNP (0.5 mg/kg, p/o) treatment for 14 days,Group 4: UC + Dexamethasone (2 mg/kg B. wt., p/o) treatment for 14 days.Average body weights were recorded at weekly intervals and colon lengths and weights were recorded after sacrifice. On the 14th day the colitis group induced by acetic acid in Cytokines viz. IL-10 and TNF-α, showed alterations in the colitis group (group 2). Histopathology of colon tissue revealed neutrophilic infiltration, disruption of epithelium and glands. Semi thin section revealed eroded villi and increase in thickness of epithelium. The control group did not show any changes in serum, tissue biomarkers and histology of the colon. Treatment with Dexamethasone showed significant amelioration as evident by rise in the antioxidant profiles and decrease in the Proinflammatory markers such as TNFα.