Vol. 10, Special Issue 1 (2021)

Author(s):
Sudheesh S Nair, Narayanan MK, Anoop S, Dhanush Krishna B, Usha Narayana Pillai and John Martin KD

Abstract:
Hematological and biochemical parameters were studied during the surgical management of clinical cases of mammary and superficial neoplasms in thirty six dogs. The dogs were studied in three groups of twelve animals each as group- I with surgery alone, group –II with neoadjuvant chemotherapy followed by surgery and group – III with surgery followed by adjuvant chemotherapy. Vinblastine- Prednisolone and Doxorubicin - Prednisolone chemotherapy protocols was adopted in six animals each in group II and III. The haematological and biochemical parameters were interpreted using repeated measures ANOVA to test the variance within the three groups on biweekly interval observations and to test the significance between three groups. Statistically significant variation (P<0.05) on mean haemoglobin, mean platelet count, Total leucocyte count, Differential Leucocyte Count (DLC) and biochemical parameters -ALP ,BUN and Creatinine values were observed within the groups and between the groups with marked change on the day of presentation in animals of group III with advanced stages of neoplasm. Hematological and biochemical parameters also showed as significant variations after the chemotherapy.